Modern SSDT CI/CD best practices for SQL Server database development (2025). PROACTIVELY activate for: (1) SSDT CI/CD pipeline design, (2) state-based deployment with DACPACs, (3) tSQLt unit testing integration, (4) database build validation in CI, (5) drift detection via SqlPackage Extract + Compare, (6) Azure DevOps and GitHub Actions templates for SSDT, (7) publish profile management per environment, (8) pre/post deploy scripts with idempotent MERGE, (9) DACPAC versioning and artifacts, (10) handling reference databases. Provides: end-to-end pipeline YAML for ADO and GHA, tSQLt setup, drift-detection scripts, and a publish-profile pattern for dev/test/prod.

This skill should be used when the user asks about ANSI, VT100, VT220, ECMA-48, ISO 6429, xterm control sequences, terminal capability detection, terminfo, environment variables, alternate screen protocols, SGR colors, OSC, CSI, DCS, terminal graphics, Windows virtual terminal processing, ConPTY, tmux/screen, SSH, or escape-sequence compatibility. PROACTIVELY activate for: escape sequences, terminal standards, capability negotiation, raw ANSI output, xterm protocols, alternate screen, color support, OSC 8 links, OSC 52 clipboard, Kitty/iTerm2 protocols, sixel, and cross-terminal fallback design. Provides: safe protocol rules, negotiation checklists, compatibility warnings, and reference tables.

This skill should be used when the user asks about TUI widgets, forms, dialogs, tables, trees, charts, command palettes, split panes, scrollbars, validation, state management, Elm/MVU architecture, async message passing, configuration, packaging, distribution, terminal security, escape-sequence injection, paste sanitization, or production hardening. PROACTIVELY activate for: widget design, validation, virtual scrolling, config/keybinding files, XDG paths, packaging, secure terminal output, and release readiness. Provides: widget contracts, state patterns, config, security, and distribution checklists.

This skill should be used when the user asks to design, review, add, drop, consolidate, or tune SQL Server indexes. PROACTIVELY activate for clustered vs nonclustered design, covering indexes and INCLUDE columns, filtered indexes, columnstore indexes, missing-index DMV interpretation, duplicate or unused indexes, index maintenance, fragmentation, fill factor, compression, partition-aligned indexes, partition elimination proof, huge-table index constraints, online/resumable rebuilds, and index changes for slow T-SQL queries. Provides: index-design decision tree, workload-aware tradeoff checklist, DMV interpretation guidance, and maintenance/rebuild patterns.

Canonical guide to authoring SKILL.md files for Claude Code plugin skills. PROACTIVELY activate for: (1) creating a new skill, (2) adding a skill to a plugin, (3) writing SKILL.md frontmatter, (4) fixing skills that never trigger, (5) organizing core vs references vs examples, (6) improving weak skill descriptions, (7) progressive disclosure design, (8) splitting oversized SKILL.md files, (9) imperative body style, (10) zero-frontmatter SKILL.md files, (11) removing boilerplate from YAML descriptions. Provides: skill template, trigger checklist, size rules, and validation process.

This skill should be used when the user asks about Unicode rendering, wcwidth, grapheme clusters, emoji, combining marks, East Asian width, BiDi text, box drawing, Nerd Fonts, color themes, truecolor, 256-color fallback, NO_COLOR, contrast, accessibility, screen-reader behavior, keyboard access, reduced motion, or non-TUI fallbacks. PROACTIVELY activate for: Unicode width bugs, misaligned tables, emoji layout, ANSI-aware string measurement, color accessibility, screen-reader friendly CLI design, plain output mode, ASCII fallback, and terminal theme support. Provides: text measurement rules, color/fallback policy, accessibility checklist, and failure-mode fixes.

Tailwind CSS accessibility patterns including WCAG 2.2 compliance, touch targets, focus management, and ARIA. PROACTIVELY activate for: (1) building accessible UI with Tailwind, (2) WCAG 2.2 compliance (Level A, AA, AAA), (3) focus rings and focus-visible styling, (4) minimum touch-target sizes (24x24/44x44), (5) color contrast and text legibility, (6) screen-reader-only utilities (sr-only, not-sr-only), (7) prefers-reduced-motion handling, (8) ARIA attribute styling (data-state, aria-* selectors), (9) keyboard navigation patterns, (10) accessible forms (label association, error announcements). Provides: WCAG 2.2 checklist, focus-management utilities, touch-target sizing recipes, sr-only patterns, and accessible component templates.

This skill should be used when the user asks to design, create, choose, modernize, or review a terminal UI, text user interface, curses app, dashboard, wizard, REPL shell, prompt flow, or CLI with interactive screens. PROACTIVELY activate for: TUI architecture, terminal-ui design, framework selection, curses vs modern framework, full-screen vs inline UI, app state modeling, widget composition, command palette, keyboard-first workflow, terminal dashboard, interactive CLI UX, and cross-platform terminal product planning. Provides: architecture patterns, framework decision rules, UX guardrails, scope boundaries, and production readiness checklists.

Tailwind CSS advanced component patterns with CVA (class-variance-authority) and variant management. PROACTIVELY activate for: (1) building reusable component variants with CVA, (2) compound variants for complex states, (3) tailwind-merge for safe class composition, (4) clsx/cn utility for conditional classes, (5) Headless UI / Radix UI primitives styled with Tailwind, (6) shadcn/ui patterns, (7) component slot patterns (asChild), (8) polymorphic components, (9) prop-driven design tokens. Provides: CVA setup recipes, cn utility implementation, compound-variant patterns, shadcn/ui-style component templates, and asChild slot examples.

This skill should be used when the user asks about TUI input handling, raw mode, cbreak mode, terminal keyboard parsing, Esc vs Alt ambiguity, Ctrl-C, shortcuts, focus management, mouse events, scroll wheel, bracketed paste, paste safety, command palettes, forms, text editing, resize events, or keybinding design. PROACTIVELY activate for: raw mode, keyboard input, keybindings, mouse support, paste handling, focus model, terminal forms, text input, vim/emacs-style shortcuts, input conflicts, and cross-platform Windows/macOS/Linux input behavior. Provides: input architecture, shortcut rules, focus patterns, paste/mouse safety, and failure-mode triage.

Complete browser-based FFmpeg system. PROACTIVELY activate for: (1) ffmpeg.wasm setup and loading, (2) Browser video transcoding, (3) React/Vue/Next.js integration, (4) SharedArrayBuffer and COOP/COEP headers, (5) Multi-threaded ffmpeg-core-mt, (6) Cloudflare Workers limitations, (7) Custom ffmpeg.wasm builds, (8) Memory management and cleanup, (9) Progress tracking and UI, (10) IndexedDB core caching. Provides: Framework-specific examples, header configuration, common operation recipes, performance optimization, troubleshooting guides. Ensures: Client-side video processing without server dependencies.

Complete Next.js Server Actions system (Next.js 15.5/16). PROACTIVELY activate for: (1) Defining Server Actions with 'use server', (2) Form handling with actions, (3) useActionState for form state, (4) useFormStatus for pending states, (5) Optimistic updates with useOptimistic, (6) Validation with Zod and next-safe-action, (7) Authorization in actions, (8) File uploads, (9) Revalidation after mutations, (10) Type-safe actions with next-safe-action library. Provides: Action patterns, form integration, validation, optimistic UI, error handling, next-safe-action integration. Ensures secure server mutations with proper validation and UX.

Complete Next.js data fetching system (Next.js 15.5/16). PROACTIVELY activate for: (1) Server Component data fetching, (2) Parallel and sequential fetching, (3) Streaming with Suspense, (4) Route Handlers (API routes), (5) Client-side fetching with SWR/TanStack Query, (6) generateStaticParams for static generation, (7) Revalidation strategies, (8) Error handling for data, (9) Async params/searchParams (Next.js 16), (10) Cache Components with 'use cache'. Provides: Fetch patterns, caching options, streaming UI, API route handlers, client fetching setup, async params pattern. Ensures optimal data loading with proper caching and error handling.

Azure Well-Architected Framework (WAF) for cloud architecture review. PROACTIVELY activate for: (1) Azure architecture review or design, (2) Reliability pillar (availability zones, geo-replication, backup/restore, RPO/RTO), (3) Security pillar (Zero Trust, encryption at rest/in transit, identity, network segmentation), (4) Cost Optimization pillar (rightsizing, reserved instances, savings plans, FinOps), (5) Operational Excellence pillar (IaC, observability, automation), (6) Performance Efficiency pillar (caching, autoscaling, async patterns), (7) Sustainability pillar, (8) WAF Reviews via the WAF Assessment Tool, (9) Microsoft Cloud Adoption Framework (CAF) alignment. Provides: pillar-by-pillar checklist, WAF assessment workflow, common antipatterns by pillar, and Azure Advisor mapping.

Complete React 19 fundamentals system. PROACTIVELY activate for: (1) React 19 new features and changes, (2) Server vs Client Components, (3) Server Actions setup, (4) use() hook usage, (5) JSX and component basics, (6) Props and state patterns, (7) Suspense and Error Boundaries, (8) Fragments and Portals. Provides: React 19 syntax, Server Component patterns, async data handling, component composition, best practices. Ensures modern React 19 patterns with proper server/client architecture.

Vitest 3 features and migration from Vitest 2 (2025). PROACTIVELY activate for: (1) Vitest 3 stable features, (2) workspace mode for monorepos, (3) test annotations and reporter API, (4) projects configuration, (5) browser mode in Vitest 3, (6) inline snapshots and toMatchInlineSnapshot, (7) typecheck mode (vitest typecheck), (8) watch mode UI improvements, (9) custom reporters, (10) migration from Jest and from Vitest 2.x. Provides: Vitest 3 changelog, workspace setup, projects config templates, browser-mode setup, and migration patterns from Jest and Vitest 2.

Complete fal.ai optimization system. PROACTIVELY activate for: (1) Queue vs run performance, (2) Parallel request batching, (3) Streaming for real-time UI, (4) WebSocket for interactive apps, (5) Model cost comparison, (6) Image size optimization, (7) Inference step tuning, (8) Webhook vs polling, (9) Result caching by seed, (10) Serverless scaling config. Provides: Parallel patterns, cost strategies, caching examples, monitoring setup. Ensures optimal performance and cost-effective usage.

Complete fal.ai text-to-image system. PROACTIVELY activate for: (1) FLUX.1/2 Pro/Dev/Schnell generation, (2) SDXL and Fast SDXL, (3) Image size presets (square_hd, landscape_16_9), (4) Guidance scale and inference steps, (5) LoRA model application, (6) Seed for reproducibility, (7) Batch generation (num_images), (8) Ideogram for text in images, (9) Recraft for design assets. Provides: Model endpoints, parameter reference, prompt engineering, quality vs speed trade-offs. Ensures optimal text-to-image generation.

Salesforce Lightning Web Components and platform features (Winter '26 / 2025). PROACTIVELY activate for: (1) authoring Lightning Web Components (LWC), (2) Wire service and @wire decorator, (3) Apex from LWC (imperative, @wire), (4) Lightning Data Service and recordEditForm/recordViewForm, (5) Lightning Design System (SLDS) styling, (6) Salesforce Mobile App development, (7) LWC events (composed, bubbles, custom events), (8) LWC testing with Jest and sfdx-lwc-jest, (9) Winter '26 platform features (new APIs, deprecations), (10) LWC + Experience Cloud customization. Provides: LWC component templates, @wire patterns, SLDS class reference, Jest test recipes, and Winter '26 changelog.

This skill should be used when the user asks to ingest, clean, validate, transform, version, monitor, or serve ML data and features. PROACTIVELY activate for: (1) data ingestion, preprocessing, feature engineering, leakage prevention, train/serving skew, (2) Spark, Dask, Polars, pandas, Ray Data, streaming pipelines, (3) Great Expectations, TFDV, Deequ, data quality and validation, (4) DVC, lakehouse tables, dataset versioning, lineage, reproducibility, (5) Feast, Tecton, Hopsworks feature stores, point-in-time joins, online/offline features. Provides: scalable, reproducible, leakage-safe ML data pipeline design.

This skill should be used when the user asks to tune hyperparameters, run sweeps, optimize search spaces, or use AutoML. PROACTIVELY activate for: (1) Optuna, Ray Tune, FLAML, AutoGluon, Hyperopt, Nevergrad, KerasTuner, W&B sweeps, (2) grid search, random search, Bayesian optimization, TPE, Gaussian processes, evolutionary search, (3) ASHA, Hyperband, successive halving, multi-fidelity optimization, population-based training, (4) learning-rate finder, batch-size search, early stopping, pruning, (5) reproducible sweep design and experiment analysis. Provides: budget-aware hyperparameter search strategy.

credit_transactions audit trail invariants and daily reconciliation patterns. PROACTIVELY activate for: (1) Designing a credit / balance / entitlement ledger, (2) credit_transactions row shape (delta, balanceAfter, reason, referenceType, referenceId, idempotencyKey), (3) Canonical idempotency key formats (refund:/debit:/stripe_checkout:/stripe_invoice:/stripe_refund:/stripe_signup_bonus:/dispute_hold:/dispute_restore:), (4) Daily reconciliation cron design (snapshot comparison, not full-sum), (5) Alert-only policy (never auto-correct drift), (6) Canonical refund helper pattern (single source of truth across pg-raw and Drizzle call sites), (7) Past_due block + credit balance shared preflight, (8) creditsDeducted boolean return pattern for pre- vs post-deduction error differentiation, (9) Money-safe email description based on resolvedVia flag, (10) Skip-users-without-baseline-snapshot reconciliation logic. Provides: table schema, canonical helper skeleton, reconciliation SQL, email gating pattern.

Unity game modding architecture and mod-loading systems. PROACTIVELY activate for: (1) adding modding support to a Unity game, (2) Asset Bundles for mods, (3) Addressables for mod content, (4) Lua scripting via MoonSharp, (5) Harmony patching for runtime IL injection, (6) Steam Workshop integration, (7) mod manager UI, (8) plugin architecture for user-generated content (UGC), (9) custom content loading at runtime, (10) sandboxing and security for untrusted mods. Provides: AssetBundle vs Addressables tradeoffs, MoonSharp setup, Harmony patch patterns, Steam Workshop SDK integration, mod manager templates, and security guidelines.

Unity multiplayer networking with NGO, Mirror, Photon, and Fish-Net. PROACTIVELY activate for: (1) building Unity multiplayer games, (2) Netcode for GameObjects (NGO) setup and patterns, (3) Mirror networking, (4) Photon PUN and Photon Fusion, (5) Fish-Net networking, (6) RPCs (ClientRpc, ServerRpc), (7) NetworkVariable and network synchronization, (8) lobby and matchmaking systems, (9) dedicated server hosting and Relay, (10) server-authoritative architecture, (11) lag compensation and prediction. Provides: networking-stack comparison, NGO templates, RPC patterns, NetworkVariable usage, lobby/matchmaking setup, and authoritative-server design.

Unity UI development with UGUI and UI Toolkit. PROACTIVELY activate for: (1) building Unity user interfaces, (2) UGUI (Canvas, RectTransform, anchors), (3) UI Toolkit (USS, UXML, VisualElement), (4) EventSystem and input handling, (5) common UI components (buttons, scroll views, dropdowns), (6) inventory UIs, HUDs, health bars, menu systems, (7) TextMeshPro setup and rich text, (8) responsive UI (anchors, layout groups), (9) runtime UI generation, (10) world-space canvases for in-game UI. Provides: UGUI vs UI Toolkit comparison, RectTransform patterns, USS/UXML examples, layout group recipes, and TextMeshPro templates.

Server-side Stripe webhook idempotency patterns. PROACTIVELY activate for: (1) Stripe webhook handler design, (2) Transactional dedup via stripe_processed_events, (3) credit_transactions.idempotency_key UNIQUE partial indexes, (4) Idempotency-Key header priority (header > body > server UUID), (5) Idempotency key format/charset/length validation at the handler edge, (6) FOR UPDATE row locking when a UPDATE depends on a prior SELECT, (7) Webhook signature verification (stripe.webhooks.constructEventAsync, tolerance, raw-body reading), (8) Retry-safe endpoints with randomUUID fallback, (9) Durable checkpoint row ordering (checkpoint FIRST, mutation SECOND). Provides: complete webhook handler skeleton, Idempotency-Key validator, dedup SQL, FOR UPDATE pattern, signature verification example.

Complete Stripe refund and dispute lifecycle handling. PROACTIVELY activate for: (1) charge.refunded handler design, (2) charge.dispute.created / charge.dispute.closed handlers, (3) Refund delta computation from event.data.previous_attributes.amount_refunded, (4) Dispute-hold past_due status management, (5) shouldRestoreStatus predicate with satisfies Record<Stripe.Dispute.Status, boolean>, (6) Credit-pack vs subscription refund differentiation, (7) Checkout Session lookup for refund proportion math, (8) Allowlist default-deny for external enums, (9) stripe.checkout.sessions.list({payment_intent}) pattern, (10) Dispute outcome branch logic (won / lost / warning_closed / prevented). Provides: full handler patterns for all three events, predicate examples, credit-pack vs subscription math, exhaustive switch patterns.

Kaggle competition notebook workflows and submissions. PROACTIVELY activate for: (1) submitting notebook outputs to competitions, (2) `kaggle competitions submit -k`, (3) downloading competition data, (4) validating submission.csv format, (5) leakage review, (6) cross-validation split design, (7) public leaderboard overfitting concerns, (8) competition rule compliance, (9) reproducible top-to-bottom notebook execution, (10) fold-aware preprocessing for ML pipelines. Provides: submission commands, validation checklist, leakage controls, and competition-ready notebook guidance.

Build type-safe validated forms in React using React Hook Form and Zod schema validation. Single schema works on both client and server for DRY validation with full TypeScript type inference via z.infer. Use when: building forms with validation, integrating shadcn/ui Form components, implementing multi-step wizards, handling dynamic field arrays with useFieldArray, or fixing uncontrolled to controlled warnings, resolver errors, async validation issues.

Build React chat interfaces with Vercel AI SDK v5/v6. Covers v6 beta (agent integration, tool approval, auto-submit), v4→v5 migration (breaking changes), useChat/useCompletion/useObject/useAssistant hooks, and 12 UI error solutions (stream parsing, stale body values, React update depth). Use when: implementing AI SDK v5/v6 chat UIs, migrating v4→v5, troubleshooting "useChat failed to parse stream", "useChat no response", or "stale body values" errors, or integrating OpenAI assistants.

Integrate TheSys C1 Generative UI API to stream interactive React components (forms, charts, tables) from LLM responses. Supports Vite+React, Next.js, and Cloudflare Workers with OpenAI, Anthropic Claude, and Workers AI. Use when building conversational UIs, AI assistants with rich interactions, or troubleshooting empty responses, theme application failures, streaming issues, or tool calling errors.

Build slide decks and presentations for research talks. Use this for making PowerPoint slides, conference presentations, seminar talks, research presentations, thesis defense slides, or any scientific talk. Provides slide structure, design templates, timing guidance, and visual validation. Works with PowerPoint and LaTeX Beamer.

Build React Native 0.76+ apps with Expo SDK 52. Covers mandatory New Architecture (0.82+), React 19 changes (propTypes/forwardRef removal), new CSS (display: contents, mixBlendMode, outline), Swift iOS template, and DevTools migration. Use when: building Expo apps, migrating to New Architecture, or troubleshooting "Fabric component not found", "propTypes not a function", "TurboModule not registered", or Swift AppDelegate errors.

Create professional research posters in LaTeX using beamerposter, tikzposter, or baposter. Support for conference presentations, academic posters, and scientific communication. Includes layout design, color schemes, multi-column formats, figure integration, and poster-specific best practices for visual communication.

Build ChatGPT apps with MCP servers on Cloudflare Workers. Extend ChatGPT with custom tools and interactive widgets (HTML/JS UI). Use when: developing ChatGPT extensions, implementing MCP servers, or troubleshooting CORS blocking (allow chatgpt.com), widget 404s (missing ui://widget/), wrong MIME type (text/html+skybridge), or ASSETS binding undefined.

21 production-ready scripts for iOS app testing, building, and automation. Provides semantic UI navigation, build automation, accessibility testing, and simulator lifecycle management. Optimized for AI agents with minimal token output.

Diffusion-based molecular docking. Predict protein-ligand binding poses from PDB/SMILES, confidence scores, virtual screening, for structure-based drug design. Not for affinity prediction.

Multi-objective optimization framework. NSGA-II, NSGA-III, MOEA/D, Pareto fronts, constraint handling, benchmarks (ZDT, DTLZ), for engineering design and optimization problems.

Use this skill for reinforcement learning tasks including training RL agents (PPO, SAC, DQN, TD3, DDPG, A2C, etc.), creating custom Gym environments, implementing callbacks for monitoring and control, using vectorized environments for parallel training, and integrating with deep RL workflows. This skill should be used when users request RL algorithm implementation, agent training, environment design, or RL experimentation.

Autonomous biomedical AI agent framework for executing complex research tasks across genomics, drug discovery, molecular biology, and clinical analysis. Use this skill when conducting multi-step biomedical research including CRISPR screening design, single-cell RNA-seq analysis, ADMET prediction, GWAS interpretation, rare disease diagnosis, or lab protocol optimization. Leverages LLM reasoning with code execution and integrated biomedical databases.

Create beautiful visual art in .png and .pdf documents using design philosophy. You should use this skill when the user asks to create a poster, piece of art, design, or other static piece. Create original visual designs, never copying existing artists' work to avoid copyright violations.

Set up Tailwind v4 with shadcn/ui using @theme inline pattern and CSS variable architecture. Four-step mandatory pattern: define CSS variables at root, map to Tailwind utilities, apply base styles, get automatic dark mode. Use when: initializing React projects with Tailwind v4, setting up shadcn/ui dark mode, or fixing colors not working, theme not applying, CSS variables broken, tw-animate-css errors, or migrating from v3.

Suite of tools for creating elaborate, multi-component claude.ai HTML artifacts using modern frontend web technologies (React, Tailwind CSS, shadcn/ui). Use for complex artifacts requiring state management, routing, or shadcn/ui components - not for simple single-file HTML/JSX artifacts.

Senior Quality Documentation Manager for comprehensive documentation control and regulatory document review. Provides document management system design, change control, configuration management, and regulatory documentation oversight. Use for document control system implementation, regulatory document review, change management, and documentation compliance verification.

Comprehensive software architecture skill for designing scalable, maintainable systems using ReactJS, NextJS, NodeJS, Express, React Native, Swift, Kotlin, Flutter, Postgres, GraphQL, Go, Python. Includes architecture diagram generation, system design patterns, tech stack decision frameworks, and dependency analysis. Use when designing system architecture, making technical decisions, creating architecture diagrams, evaluating trade-offs, or defining integration patterns.

Master REST and GraphQL API design principles to build intuitive, scalable, and maintainable APIs that delight developers. Use when designing new APIs, reviewing API specifications, or establishing API design standards.

World-class data science skill for statistical modeling, experimentation, causal inference, and advanced analytics. Expertise in Python (NumPy, Pandas, Scikit-learn), R, SQL, statistical methods, A/B testing, time series, and business intelligence. Includes experiment design, feature engineering, model evaluation, and stakeholder communication. Use when designing experiments, building predictive models, performing causal analysis, or driving data-driven decisions.

World-class prompt engineering skill for LLM optimization, prompt patterns, structured outputs, and AI product development. Expertise in Claude, GPT-4, prompt design patterns, few-shot learning, chain-of-thought, and AI evaluation. Includes RAG optimization, agent design, and LLM system architecture. Use when building AI products, optimizing LLM performance, designing agentic systems, or implementing advanced prompting techniques.

Generate testable hypotheses. Formulate from observations, design experiments, explore competing explanations, develop predictions, propose mechanisms, for scientific inquiry across domains.

Senior Information Security Manager specializing in ISO 27001 and ISO 27002 implementation for HealthTech and MedTech companies. Provides ISMS implementation, cybersecurity risk assessment, security controls management, and compliance oversight. Use for ISMS design, security risk assessments, control implementation, and ISO 27001 certification activities.

Comprehensive frontend development skill for building modern, performant web applications using ReactJS, NextJS, TypeScript, Tailwind CSS. Includes component scaffolding, performance optimization, bundle analysis, and UI best practices. Use when developing frontend features, optimizing performance, implementing UI/UX designs, managing state, or reviewing frontend code.

Comprehensive fullstack development skill for building complete web applications with React, Next.js, Node.js, GraphQL, and PostgreSQL. Includes project scaffolding, code quality analysis, architecture patterns, and complete tech stack guidance. Use when building new projects, analyzing code quality, implementing design patterns, or setting up development workflows.

Toolkit for interacting with and testing local web applications using Playwright. Supports verifying frontend functionality, debugging UI behavior, capturing browser screenshots, and viewing browser logs.

Comprehensive toolkit for protein language models including ESM3 (generative multimodal protein design across sequence, structure, and function) and ESM C (efficient protein embeddings and representations). Use this skill when working with protein sequences, structures, or function prediction; designing novel proteins; generating protein embeddings; performing inverse folding; or conducting protein engineering tasks. Supports both local model usage and cloud-based Forge API for scalable inference.

State-space model with O(n) complexity vs Transformers' O(n²). 5× faster inference, million-token sequences, no KV cache. Selective SSM with hardware-aware design. Mamba-1 (d_state=16) and Mamba-2 (d_state=128, multi-head). Models 130M-2.8B on HuggingFace.

ISO 13485 Quality Management System specialist for medical device companies. Provides QMS implementation, maintenance, process optimization, and compliance expertise. Use for QMS design, documentation control, management review, internal auditing, corrective actions, and ISO 13485 certification activities.

Evaluate research rigor. Assess methodology, experimental design, statistical validity, biases, confounding, evidence quality (GRADE, Cochrane ROB), for critical analysis of scientific claims.

Systematic peer review toolkit. Evaluate methodology, statistics, design, reproducibility, ethics, figure integrity, reporting standards, for manuscript and grant review across disciplines.

UX research and design toolkit for Senior UX Designer/Researcher including data-driven persona generation, journey mapping, usability testing frameworks, and research synthesis. Use for user research, persona creation, journey mapping, and design validation.

Strategic product leadership toolkit for Head of Product including OKR cascade generation, market analysis, vision setting, and team scaling. Use for strategic planning, goal alignment, competitive analysis, and organizational design.

UI design system toolkit for Senior UI Designer including design token generation, component documentation, responsive design calculations, and developer handoff tools. Use for creating design systems, maintaining visual consistency, and facilitating design-dev collaboration.

Complete browser automation with Playwright. Auto-detects dev servers, writes clean test scripts to /tmp. Test pages, fill forms, take screenshots, check responsive design, validate UX, test login flows, check links, automate any browser task. Use when user wants to test websites, automate browser interactions, validate web functionality, or perform any browser-based testing.

Build production-ready Node.js backend services with Express/Fastify, implementing middleware patterns, error handling, authentication, database integration, and API design best practices. Use when creating Node.js servers, REST APIs, GraphQL backends, or microservices architectures.

Design microservices architectures with service boundaries, event-driven communication, and resilience patterns. Use when building distributed systems, decomposing monoliths, or implementing microservices.

Implement proven backend architecture patterns including Clean Architecture, Hexagonal Architecture, and Domain-Driven Design. Use when architecting complex backend systems or refactoring existing applications for better maintainability.

Design a PostgreSQL-specific schema. Covers best-practices, data types, indexing, constraints, performance patterns, and advanced features

Design LLM applications using the LangChain framework with agents, memory, and tool integration patterns. Use when building LangChain applications, implementing AI agents, or creating complex LLM workflows.

Create distinctive, production-grade frontend interfaces with high design quality. Use this skill when the user asks to build web components, pages, or applications. Generates creative, polished code that avoids generic AI aesthetics.

Guide users through creating Agent Skills for Claude Code. Use when the user wants to create, write, author, or design a new Skill, or needs help with SKILL.md files, frontmatter, or skill structure.

Design multi-stage CI/CD pipelines with approval gates, security checks, and deployment orchestration. Use when architecting deployment workflows, setting up continuous delivery, or implementing GitOps practices.

Diffusion-based molecular docking. Predict protein-ligand binding poses from PDB/SMILES, confidence scores, virtual screening, for structure-based drug design. Not for affinity prediction.

Multi-objective optimization framework. NSGA-II, NSGA-III, MOEA/D, Pareto fronts, constraint handling, benchmarks (ZDT, DTLZ), for engineering design and optimization problems.

Autonomous biomedical AI agent framework for executing complex research tasks across genomics, drug discovery, molecular biology, and clinical analysis. Use this skill when conducting multi-step biomedical research including CRISPR screening design, single-cell RNA-seq analysis, ADMET prediction, GWAS interpretation, rare disease diagnosis, or lab protocol optimization. Leverages LLM reasoning with code execution and integrated biomedical databases.

Suite of tools for creating elaborate, multi-component claude.ai HTML artifacts using modern frontend web technologies (React, Tailwind CSS, shadcn/ui). Use for complex artifacts requiring state management, routing, or shadcn/ui components - not for simple single-file HTML/JSX artifacts.

Generate testable hypotheses. Formulate from observations, design experiments, explore competing explanations, develop predictions, propose mechanisms, for scientific inquiry across domains.

Comprehensive toolkit for protein language models including ESM3 (generative multimodal protein design across sequence, structure, and function) and ESM C (efficient protein embeddings and representations). Use this skill when working with protein sequences, structures, or function prediction; designing novel proteins; generating protein embeddings; performing inverse folding; or conducting protein engineering tasks. Supports both local model usage and cloud-based Forge API for scalable inference.

Build production-ready Node.js backend services with Express/Fastify, implementing middleware patterns, error handling, authentication, database integration, and API design best practices. Use when creating Node.js servers, REST APIs, GraphQL backends, or microservices architectures.

Evaluate research rigor. Assess methodology, experimental design, statistical validity, biases, confounding, evidence quality (GRADE, Cochrane ROB), for critical analysis of scientific claims.

Master REST and GraphQL API design principles to build intuitive, scalable, and maintainable APIs that delight developers. Use when designing new APIs, reviewing API specifications, or establishing API design standards.

Systematic peer review toolkit. Evaluate methodology, statistics, design, reproducibility, ethics, figure integrity, reporting standards, for manuscript and grant review across disciplines.

Design microservices architectures with service boundaries, event-driven communication, and resilience patterns. Use when building distributed systems, decomposing monoliths, or implementing microservices.

Design, organize, and manage Helm charts for templating and packaging Kubernetes applications with reusable configurations. Use when creating Helm charts, packaging Kubernetes applications, or implementing templated deployments.

Create beautiful visual art in .png and .pdf documents using design philosophy. You should use this skill when the user asks to create a poster, piece of art, design, or other static piece. Create original visual designs, never copying existing artists' work to avoid copyright violations.

Implement proven backend architecture patterns including Clean Architecture, Hexagonal Architecture, and Domain-Driven Design. Use when architecting complex backend systems or refactoring existing applications for better maintainability.

Design LLM applications using the LangChain framework with agents, memory, and tool integration patterns. Use when building LangChain applications, implementing AI agents, or creating complex LLM workflows.

Toolkit for interacting with and testing local web applications using Playwright. Supports verifying frontend functionality, debugging UI behavior, capturing browser screenshots, and viewing browser logs.

Design multi-stage CI/CD pipelines with approval gates, security checks, and deployment orchestration. Use when architecting deployment workflows, setting up continuous delivery, or implementing GitOps practices.

Design multi-cloud architectures using a decision framework to select and integrate services across AWS, Azure, and GCP. Use when building multi-cloud systems, avoiding vendor lock-in, or leveraging best-of-breed services from multiple providers.

Use when design is complete and you need detailed implementation tasks for engineers with zero codebase context - creates comprehensive implementation plans with exact file paths, complete code examples, and verification steps assuming engineer has minimal domain knowledge

Containerized README-screenshot pipeline (Docker + Playwright) for ComfyUI custom-node packs. Use when generating pack screenshots, adding `just screenshots`, or capturing modal/gesture node UI.

Version badge UI showing build version, git commit, and changelog in a tooltip. Use when adding version visibility for support or debugging. Works with React, Vue, Svelte, and JS.

UX testing: Playwright E2E, axe-core a11y, visual regression. Use when setting up E2E testing, screenshot assertions, browser automation, or a11y CI workflows.

Generative UI framework that renders AI-generated JSON specs into type-safe UI components across React, Vue, Svelte, Solid, React Native, video, PDF, and email.

HTML-native design skill for AI coding agents — high-fidelity prototypes, slides, animations, and MP4 export with 20 design philosophies and 5-dimension critique

Playwright E2E testing — cross-browser, visual regression, API testing, mobile emulation. Use when writing E2E tests or setting up automated UI testing for web apps.

Derive Claude rules from git commit history. Use when extracting implicit decisions from commits or codifying code-style, testing, and API-design rules.