Mass spectrometry toolkit (OpenMS Python). Process mzML/mzXML, peak picking, feature detection, peptide ID, proteomics/metabolomics workflows, for LC-MS/MS analysis.

Statistical visualization. Scatter, box, violin, heatmaps, pair plots, regression, correlation matrices, KDE, faceted plots, for exploratory analysis and publication figures.

Creating algorithmic art using p5.js with seeded randomness and interactive parameter exploration. Use this when users request creating art using code, generative art, algorithmic art, flow fields, or particle systems. Create original algorithmic art rather than copying existing artists' work to avoid copyright violations.

Query CZ CELLxGENE Census (61M+ cells). Filter by cell type/tissue/disease, retrieve expression data, integrate with scanpy/PyTorch, for population-scale single-cell analysis.

Constraint-based metabolic modeling (COBRA). FBA, FVA, gene knockouts, flux sampling, SBML models, for systems biology and metabolic engineering analysis.

Access NCBI GEO for gene expression/genomics data. Search/download microarray and RNA-seq datasets (GSE, GSM, GPL), retrieve SOFT/Matrix files, for transcriptomics and expression analysis.

Query NHGRI-EBI GWAS Catalog for SNP-trait associations. Search variants by rs ID, disease/trait, gene, retrieve p-values and summary statistics, for genetic epidemiology and polygenic risk scores.

Biological data toolkit. Sequence analysis, alignments, phylogenetic trees, diversity metrics (alpha/beta, UniFrac), ordination (PCoA), PERMANOVA, FASTA/Newick I/O, for microbiome analysis.

UMAP dimensionality reduction. Fast nonlinear manifold learning for 2D/3D visualization, clustering preprocessing (HDBSCAN), supervised/parametric UMAP, for high-dimensional data.

Access ZINC (230M+ purchasable compounds). Search by ZINC ID/SMILES, similarity searches, 3D-ready structures for docking, analog discovery, for virtual screening and drug discovery.

Expert guidance for ffuf web fuzzing during penetration testing, including authenticated fuzzing with raw requests, auto-calibration, and result analysis

Access AlphaFold's 200M+ AI-predicted protein structures. Retrieve structures by UniProt ID, download PDB/mmCIF files, analyze confidence metrics (pLDDT, PAE), for drug discovery and structural biology.

Master the uv package manager for fast Python dependency management, virtual environments, and modern Python project workflows. Use when setting up Python projects, managing dependencies, or optimizing Python development workflows with uv.

A set of resources to help me write all kinds of internal communications, using the formats that my company likes to use. Claude should use this skill whenever asked to write some sort of internal communications (status reports, leadership updates, 3P updates, company newsletters, FAQs, incident reports, project updates, etc.).

Access RCSB PDB for 3D protein/nucleic acid structures. Search by text/sequence/structure, download coordinates (PDB/mmCIF), retrieve metadata, for structural biology and drug discovery.

Maintain skills wiki health - check links, naming, cross-references, and coverage

Research ideation partner. Generate hypotheses, explore interdisciplinary connections, challenge assumptions, develop methodologies, identify research gaps, for creative scientific problem-solving.

Access Human Metabolome Database (220K+ metabolites). Search by name/ID/structure, retrieve chemical properties, biomarker data, NMR/MS spectra, pathways, for metabolomics and identification.

Create distributable Python packages with proper project structure, setup.py/pyproject.toml, and publishing to PyPI. Use when packaging Python libraries, creating CLI tools, or distributing Python code.

Understand how ideas evolved over time to find old solutions for new problems and avoid repeating past failures

Intelligently organizes your files and folders across your computer by understanding context, finding duplicates, suggesting better structures, and automating cleanup tasks. Reduces cognitive load and keeps your digital workspace tidy without manual effort.

Implement NFT standards (ERC-721, ERC-1155) with proper metadata handling, minting strategies, and marketplace integration. Use when creating NFT contracts, building NFT marketplaces, or implementing digital asset systems.

Create algorithmic art using p5.js with seeded randomness, flow fields, and particle systems. Use when you need to generate generative art, create computational aesthetics, or build interactive artistic visualizations. Automatically activates when discussing: "generative art", "algorithmic art", "p5.js visualization", "computational aesthetics".

Use when tests have race conditions, timing dependencies, or inconsistent pass/fail behavior - replaces arbitrary timeouts with condition polling to wait for actual state changes, eliminating flaky tests from timing guesses

Recognize when disagreements reveal valuable context, preserve multiple valid approaches instead of forcing premature resolution

Use when errors occur deep in execution and you need to trace back to find the original trigger - systematically traces bugs backward through call stack, adding instrumentation when needed, to identify source of invalid data or incorrect behavior

Sync local skills repository with upstream changes from obra/superpowers-skills

Dispatch to the right problem-solving technique based on how you're stuck

Force unrelated concepts together to discover emergent properties - "What if we treated X like Y?"

Flip core assumptions to reveal hidden constraints and alternative approaches - "what if the opposite were true?"

Find one insight that eliminates multiple components - "if this is true, we don't need X, Y, or Z"

Spot patterns appearing in 3+ domains to find universal principles

Use when starting feature work that needs isolation from current workspace or before executing implementation plans - creates isolated git worktrees with smart directory selection and safety verification

Use when implementation is complete, all tests pass, and you need to decide how to integrate the work - guides completion of development work by presenting structured options for merge, PR, or cleanup

Use when you've developed a broadly useful skill and want to contribute it upstream via pull request - guides process of branching, committing, pushing, and creating PR to contribute skills back to upstream repository

Use when about to claim work is complete, fixed, or passing, before committing or creating PRs - requires running verification commands and confirming output before making any success claims; evidence before assertions always

Use when invalid data causes failures deep in execution, requiring validation at multiple system layers - validates at every layer data passes through to make bugs structurally impossible

Picks random winners from lists, spreadsheets, or Google Sheets for giveaways, raffles, and contests. Ensures fair, unbiased selection with transparency.

Replace with description of the skill and when Claude should use it.

Detect coworker Claude agents in a shared checkout. Use when starting a session in a shared clone, before destructive git ops (stash, reset, checkout), or before bulk-edit / commit-loop workflows.

Submit a diverged-fork commit to upstream as a clean PR via cherry-pick with re-derive fallback, message scrubbing, and regression checks. Use when direct rebase fails.

Generate project-specific rules from PRDs for Blueprint Development. Use when generating architecture, testing, or quality rules from requirements documents.

Block manual edits to release-please files (CHANGELOG, version fields). Use when editing changelogs, bumping versions, or releasing to avoid conflicting with automation.

Derive PRDs, ADRs, PRPs from git history, docs, and codebase. Use when onboarding a project to blueprint, generating a PRD or ADRs retroactively, or extracting features from conventional commits.

Manage multi-package Python projects with uv workspaces. Use when the user mentions uv workspaces, Python monorepo, shared lockfiles, or member dependencies.

Discover child blueprint workspaces and refresh the manifest. Use when adding/removing a child blueprint or when status shows stale portfolio data.

Upgrade blueprint structure to the latest format version. Use when migrating between format versions, enabling monorepo workspaces, or batch upgrading repos.

Execute a PRP with validation loop, TDD, and quality gates. Use when asked to execute a PRP, run a planned feature from docs/prps/, or delegate a PRP to subagents.

Install and manage Python interpreter versions with uv. Use when the user mentions installing Python versions, .python-version, uv python, or managing CPython/PyPy.

Python linting with ruff. Fast linting, rule selection, auto-fixing, and config. Use when checking Python code quality, enforcing standards, or finding bugs.

Python project setup, deps, and lockfiles with uv. Use when the user mentions uv, creating Python projects, managing dependencies, lockfiles, or pyproject.toml.

Generate a PermissionRequest hook with auto-approve/deny rules. Use when needing a safer alternative to --dangerouslySkipPermissions tailored to your project stack.

TypeScript strict mode: tsconfig.json, strict flags, Bundler/NodeNext moduleResolution, verbatimModuleSyntax. Use when setting up TS or migrating to stricter type safety.

Install and manage global Python CLI tools with uv (pipx alternative). Use when the user mentions uv tool, uvx, installing CLI tools globally, or pipx replacement.

Electron desktop app that captures web traffic via Chrome DevTools Protocol and uses AI to generate protocol analysis reports

Analyze session for skill feedback and create GitHub issues. Use when a skill gave wrong guidance, a command failed, you found a better pattern, or a skill worked well.

GO Feature Flag (GOFF) self-hosted feature flags with OpenFeature integration — config, relay proxy, targeting, rollouts. Use when working with GOFF or flags.goff.yaml.

Manage Helm values — override precedence, multi-env configs, --set, schema validation, secrets. Use when the user mentions Helm values, env-specific configs, or values.yaml.

Skill for building, configuring, and extending LSFG-Android — a Vulkan frame-generation overlay for Android using lsfg-vk via MediaProjection capture.

TypeScript bot implementing dump-and-hedge arbitrage strategy on Polymarket 15-minute Up/Down prediction markets with CLOB order execution and simulation mode.

Android app manager with VPN integration that freezes/unfreezes app groups based on VPN connection state using Shizuku's pm disable-user

Basedpyright static type checker for Python. Use when setting up type checking, configuring LSP, or comparing type checkers (basedpyright, pyright, mypy alternative).

Blueprint meta command: determine and execute the next logical action. Use when asked 'what's next?', 'continue blueprint', or 'run blueprint' without a subcommand.

Expert knowledge for building, configuring, and operating GooseRelayVPN — a SOCKS5 VPN that tunnels raw TCP through Google Apps Script to a VPS exit server using AES-256-GCM encryption and domain fronting.

Expert skill for memory-lancedb-pro — a production-grade LanceDB-backed long-term memory plugin for OpenClaw agents with hybrid retrieval, cross-encoder reranking, multi-scope isolation, and smart auto-capture.

Package managers: uv (Python), bun (TypeScript). Use when setting up uv or bun, migrating from pip/npm/yarn/poetry/pipenv, or resolving lockfile conflicts.

Home Assistant automation creation and management. Use when working with HA triggers, conditions, actions, scripts, scenes, or blueprints.

Open-source Luau/Lua script IDE and executor built as a Windows Forms C# application with Monaco editor integration

Core Python development idioms and language features (3.10+). Use when mentioning Python, type hints, or async. For scripts see uv-run; for project setup see uv-project-management.

Open-source Chrome extension replacing 12+ browser extensions with privacy-respecting tools including tab cleaner, cookie editor, dark mode, JS toggle, GDPR dismisser, and more.

Vulture and deadcode tools for detecting unused Python code (functions, classes, imports). Use when cleaning up codebases or removing dead code. Triggers vulture, deadcode.

Find and replace code patterns structurally with ast-grep. Use when matching code by AST structure, finding functions with specific signatures, or detecting anti-patterns regex cannot match.

Expert skill for Capso, the open-source macOS screenshot and screen recording app built with Swift 6 and SwiftUI — covers architecture, building from source, package APIs, and contributing.

README.md with logo, badges, features, tech stack sections. Use when creating a README, auditing missing sections, or adding shields.io badges.

Home Assistant entity and domain management. Use when working with entity IDs, device classes, template entities, groups, or domain-specific attribute customizations.

Free open-source macOS cleaner built with SwiftUI — CleanMyMac alternative with zero telemetry, scheduled auto-cleaning, and Xcode/Homebrew/system cache cleanup.

Advanced uv dependencies: Git deps, path deps, editable installs, groups, extras, custom indexes. Use when the user mentions git+https deps, editable installs, or private indexes.

WildWorld large-scale action-conditioned world modeling dataset with 108M+ frames from a photorealistic ARPG game, featuring per-frame annotations, 450+ actions, and explicit state information for generative world modeling research.

LaTeX CV/resume templates for PhD students and researchers, covering ATS-optimized industry resumes and full academic CVs.

Biome all-in-one JS/TS formatter and linter, 15-20x faster than ESLint/Prettier. Use when setting up formatting/linting or migrating from ESLint+Prettier.

Expertise in the Create Simulated Project — a NeoForge Minecraft mod suite adding physics-based contraptions including planes, airships, cars, and land vehicles built on the Create mod framework.

Comprehensive guide for contributing to and working with freeCodeCamp's open-source codebase and curriculum platform

Self-hosted ML coding practice platform with 68 problems covering Transformers, diffusion, RLHF, and more — instant browser feedback, no GPU required.

Analyze docs quality across PRDs, ADRs, PRPs, CLAUDE.md, .claude/rules/. Use when auditing documentation, checking for stale ADRs/PRDs, or validating rule frontmatter structure.

AI-powered green screen keyer that unmixes foreground colors and generates clean linear alpha channels using neural networks

Browser-based preset manager and RAW converter for Fujifilm X-series cameras using WebUSB and PTP protocol

GitHub issue admin operations. Use when transferring issues, pinning, locking discussions, creating dev branches from issues, bulk ops, or managing custom fields.

End-to-end protocol replay toolkit for ChatGPT Team subscription with hCaptcha solver and anti-fraud research tools

Expert knowledge for setting up, configuring, and extending Grimmory — a self-hosted book library manager supporting EPUBs, PDFs, comics, Kobo sync, OPDS, and multi-user management.

Generate high-quality 3D human and humanoid robot motions using Kimodo, a kinematic motion diffusion model controlled via text prompts and kinematic constraints.

Expert skill for building, running, and extending MinecraftConsoles (Minecraft Legacy Console Edition) — a C++ multi-platform reimplementation with dedicated server, LAN multiplayer, and modding support.

One-click model liberation toolkit for removing refusal behaviors from LLMs via surgical abliteration techniques

OpenClaw-RL framework for training personalized AI agents via reinforcement learning from natural conversation feedback

Expert skill for using OpenViking, the open-source context database for AI Agents that manages memory, resources, and skills via a filesystem paradigm.

Python code formatting with ruff format. Fast, Black-compatible formatter. Use when formatting Python files, enforcing style, or checking format compliance.

NieR:Automata themed Hyprland + Quickshell + Waybar rice for Arch Linux with QML widgets